Swelling of the liver causes
Cirrhosis and edema
The outflow of blood from the liver is broken, which increasesblood filling of internal organs and lymphogenesis in the liver. The increase in pressure in the veins of the liver is a powerful stimulus that causes a delay in Na + in the kidneys and, probably, a fall in the OPSS and an effective arterial volume. Due to the violation of albumin synthesis, hypoalbuminemia is often associated. and the effective arterial volume is further reduced. As a result, the renin-angiotensin system is activated and the tone of the sympathetic nerves rises. innervating the kidneys. The inactivation of aldosterone in the liver slows down, and its level increases. In the beginning, the excess of extracellular fluid is in the basin of the portal vein and the lymphatic vessels of the liver, that is, in the abdominal cavity; in the future, especially against the background of hypoalbuminemia. generalized edema is possible. The increased synthesis of prostaglandins E2 and I2 in liver cirrhosis reduces the delay of Na +. In such patients, NSAIDs. blocking the formation of prostaglandins, impair kidney function and increase the delay of Na +.
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