Diclofenac for edema

Tablets, covered with an enteric-soluble coat, 25 mg each.

Retard tablets, covered with enteric-soluble coat, 100 mg each.

1 tablet contains: Active ingredient: diclofenac sodium 25 mg.
Excipients: lactose, wheat starch, microcrystalline cellulose, colloidal silicon dioxide, povidone, magnesium stearate, sheath.

1 tablet contains: Active ingredient: diclofenac sodium 100 mg.
Excipients: lactose, microcrystalline cellulose, methocel E 15, colloidal silicon dioxide, magnesium stearate, sheath.

Diclofenac is a non-steroidal anti-inflammatory drug with a pronounced anti-inflammatory, analgesic and antipyretic effect. A derivative of phenylacetic acid.

Inhibits the activity of the enzyme cyclooxygenase andthus disrupts the metabolism of arachidonic acid, reducing the formation of progenitors of prostaglandins and thromboxanes. The analgesic effect is associated with the inhibition of local synthesis of prostaglandins, as well as other substances that increase the sensitivity of pain receptors to chemical irritation. Antipyretic effect is associated with direct influence on the center of thermoregulation in the hypothalamus. In rheumatic diseases, the anti-inflammatory and analgesic effect of diclofenac significantly reduces the severity of pain, morning stiffness, swelling of the joints, which improves the functional state of the patient. In injuries, in the postoperative period, diclofenac reduces pain and inflammatory edema.

After oral administration, quickly and completelyabsorbed. The maximum concentration after taking retard 100 mg tablets is reached after 4 hours and is 0.5 μg / ml. 99% of diclofenac binds to plasma proteins, namely albumins. Diclofenac penetrates into the synovial fluid, where the maximum concentration is reached 2-4 hours later than in the plasma. When ingesting about 50% of diclofenac is metabolized in the liver "at the first pass." The systemic clearance of the active substance is approximately 263 ml / min. Half-life is 1-2 hours. Approximately 60% is excreted by the kidneys in the form of metabolites, less than 1% is unchanged in the urine, the rest is excreted as metabolites with bile.

Diclofenac is used for:
  • acute arthritis of various genesis (including gout);
  • chronic arthritis, especially with rheumatic arthritis (chronic polyarthritis);
  • juvenile chronic polyarthritis;
  • ankylosing spondylitis (Bechterew's disease) and other inflammatory-rheumatic diseases of the spine;
  • arthrosis and spondyloarthrosis (inflammation in degenerative diseases of the joints and spine);
  • rheumatism of soft tissues;
  • painful swelling and inflammation after trauma and surgical interventions;
  • non-rheumatic inflammatory pain conditions.
Contraindications
  • erosive-ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
  • information about attacks of bronchial asthma, hives, acute rhinitis associated with the use of acetylsalicylic acid or other NSAIDs;
  • increased sensitivity to diclofenac or drug components;
  • disorders of hematopoiesis of unknown etiology;
  • III trimester of pregnancy;
  • children's age till 6 years.
Caveats

With special care appoint the drugpatients with diseases of the liver, kidney and gastrointestinal tract in history, with bronchial asthma, allergic ("hay") runny nose, polyps of the nasal mucosa, dyspeptic symptoms at the time of prescription, arterial hypertension, heart failure, immediately after serious surgical interventions, in the first and second trimesters of pregnancy and lactation, as well as the elderly. Because of the high content of active ingredient, retard tablets of 100 mg are not recommended for children under 18 years of age.

During treatment with the drug should be carried outsystematic monitoring of the pattern of peripheral blood, liver function, kidney function, feces for blood. Patients taking the drug should refrain from types of action that require increased attention and rapid mental and motor reactions, alcohol consumption.

Interaction with other drugs

With the simultaneous use of diclofenac and:
  • digoxin, phenytoin, or lithium preparations - plasma levels of these drugs may increase;
  • diuretics and hypotensive drugs - the effect of these drugs may decrease;
  • potassium-sparing diuretics - there may be hyperkalemia;
  • other NSAIDs or glucocorticoids - there is an increased risk of side effects from the gastrointestinal tract;
  • acetylsalicylic acid - there can be a decrease in the concentration of diclofenac in the blood serum;
  • cyclosporine - the toxic effect of the latter on the kidneys may increase;
  • antidiabetics - can cause hypo- or hyperglycemia;
  • Methotrexate within 24 hours before or after its administration may increase the concentration of methotrexate and increase its toxicity;
  • anticoagulants - regular blood clotting is necessary.
Dosing and Administration

The drug is taken orally, without chewing with a sufficient amount of fluid at the end or after eating.

Dosages and duration of treatmentestablishes the attending physician depending on the features of the course of the disease and the severity of the condition. With rheumatic diseases treatment can be long. Usually the recommended dose for adults varies between 50-150 mg of diclofenac sodium per day, divided into 2-3 doses. The maximum daily dose is 150 mg.

Retard tablets are usually prescribed 1 time per day in a single dose of 100 mg. Children older than 6 years of age, the recommended dose is 1-2 mg / kg body weight per day, divided into 2-3 doses.

From the gastrointestinal tract: nausea, vomiting, diarrhea, indigestion, flatulence, anorexia, constipation; In rare cases, the occurrence of erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract.

From the nervous system: sometimes there is headache, dizziness, sleep disturbances (insomnia or drowsiness), agitation; In some cases violations of sensitivity, disorientation, memory, sight, hearing, taste, tinnitus, convulsions, tremor, mental disorders, depression, anxiety, aseptic meningitis have been noted.

Allergic manifestations: skin rash, rarely urticaria, isolated cases of eczema, polymorphic erythema, erythroderma, rarely had attacks of bronchial asthma, systemic anaphylactic reactions, in some cases - vasculitis, pneumonitis.

From the kidneys: rarely - edema, in some cases, acute renal failure, interstitial nephritis, nephrotic syndrome, hematuria, proteinuria.

On the part of the liver: a transient increase in the activity of transaminases in the blood, rarely - hepatitis, in some cases - fulminant hepatitis.

From the hemopoietic system: individual cases of thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia are described.

From the side of the cardiovascular system: single cases of tachycardia, arterial hypertension, congestive heart failure are noted.

Symptoms: The clinical picture is determined by violations from the central nervous system (headache, dizziness, increased excitability, hyperventilation with increased convulsive readiness and gastrointestinal disturbances (abdominal pain, nausea, vomiting).

Treatment: There is no specific antidote. It requires intensive medical care and symptomatic treatment.

Tablets, covered with enteric-soluble coating, 25 mg; 30 pieces in one package.

Retard tablets covered with enteric-soluble coat, 100 mg each; 30 pieces in one package.

In a dry and dark place attemperature not more than 25 ° С. Keep out of the reach of children! Keep away from direct sunlight! Do not store in damp areas, such as bathrooms, etc.

Tablets of 25 mg - 3 years from the date of release.

Tablets retard for 100 mg - 2 years from the date of release

Conditions of leave from pharmacies

1% gel for external use.

The gel contains: Active substance: diclofenac sodium - 1%.
Excipients: carbomer, macrogol, propylene glycol, sodium benzoate, ethyl alcohol, distilled water.

Diclofenac-gel has a localanti-inflammatory and analgesic effect. Inhibiting the synthesis of prostaglandins, the drug reduces pain caused by inflammation, swelling and flushing. When topical application causes the weakening or disappearance of pain in the place of application of the gel, including joint pain at rest and during movement, reduces morning stiffness and swelling of the joints. Promotes an increase in the volume of movements.

Inflammatory and degenerative diseasesjoints; rheumatism of soft tissues; traumatic bruises, sprains of ligaments, muscles and tendons; inflammatory edema of soft tissues, soreness of muscles and joints, caused by heavy physical stress.

Contraindications
  • known individual hypersensitivity to diclofenac or to the components of the drug;
  • bronchial asthma, urticaria or rhinitis, triggered by the use of acetylsalicylic acid (salicylates) or other NSAIDs;
  • peptic ulcer of stomach and duodenum in the phase of exacerbation;
  • pregnancy and the period of breastfeeding;
  • children under 1 year.
Caveats Avoid exposure todamaged skin surface, open wounds, eyes and mucous membranes. Before using the gel, diclofenac should be consulted with a doctor if you:</ li>
  • peptic ulcer of stomach and 12-colon in the anamnesis;
  • impaired liver and kidney function;
  • bronchial asthma, rhinitis, polyps of the nasal mucosa;
  • allergic reactions in the anamnesis.</ p>

    Do not use Diclofenac gel in children under 6 years old without consulting a doctor.

    Interaction with other drugs

    You should consult your doctor before using the gel if you are under medical supervision or apply other NSAIDs.

    Dosing and Administration

    OUTSIDE! A small amount of gel (2-4 g) is applied to the affected parts of the body and rubbed into the skin with light movements until it is completely absorbed 2-3 times a day. The duration of the course of treatment should not exceed 14 days without consulting a doctor.

    The resulting side effects depend onindividual sensitivity, the magnitude of the applied dose and the duration of treatment. There may be allergic reactions from the skin - skin rash, burning, redness. With long-term use and / or use of large amounts, systemic side effects may arise: from the gastrointestinal tract (pain in the epigastric region, nausea, flatulence, loss of appetite); from the central nervous system (headache, headache, drowsiness); from the respiratory system (bronchospasm, systemic anaphylactic reactions, including shock).

    If there are any side effects, stop using the gel and consult a doctor.

    1% gel in tubes of 60 g.

    Store in a dry place at a temperature of no higher than 25 ° C. Keep out of the reach of children!

    2 years from the date of issue. Do not use the drug with expired shelf life.

    Conditions of leave from pharmacies