Antidiarrheal remedy

The invention relates to the field of medicine and canbe used for the manufacture of medical and cosmetic products in the form of ointments, creams, emulsions, lotions, gels, used as a decongestant. The invention consists in that the external decongestant comprises a base, a desired phosphonate additive, a soluble magnesium salt. The agent may additionally contain medicinal, and / or flavoring, and / or biologically active additives. The invention provides an increase in the effectiveness of anti-edematous action. 2 z.p. f-ly.

Limited Liability Company "Institute of Pharmaceutical Reagents Repharm"

(EN) The invention relates to the field of cosmetology andmedicine and can be used for the manufacture of medical and cosmetic products in the form of ointments, creams, emulsions, lotions, gels, used as a decongestant.
External medical and cosmetic means,manufactured in various forms, for example in the form of creams, ointments, gels, and the like. always contain a physiologically acceptable base and various target additives. In the base, components such as a lipid carrier, an emulsifier, a thickener, a preservative, a solvent are usually introduced. With the most common application of already known standard cosmetic or therapeutic bases, changes are introduced into the composition of additives.
As additives in medical-cosmeticthe most widely used medicines, biologically active additives, essential oils, fruit acids, flavors, dyes, various chemical compounds, both organic and inorganic, of synthetic or natural origin.
Certain interest for a new inventionrepresent known compositions containing magnesium salts. It is known from the prior art to use soluble magnesium salts, namely magnesium chloride, magnesium sulfate, magnesium acetate in cosmetic and therapeutic compositions used, for example, in facial cleansing lotions / Japan, Patent 62-258312; A 61 K 7/00, 1987; S.A. 1988, 108: 209994), saline cream nourishing action / Japan, patent 8175962; A 61 to 7/48, 1996; C.A. 1996, 125: 177006), as a part of cosmetic means preventing skin dryness / Japan, patent 62-209010; A 61 K 7/00, 1987; S.A. 1988, 108: 101113). However, the use of magnesium salts in the formulation of decongestants has not been identified.
As a decongestant, as well as a means for treating other diseases, a well-known composition, chosen as a prototype for a new composition, is used.
This external agent for treatmentneurological diseases, diseases of the musculoskeletal system with pain syndrome and edema, contains 0.5-3 wt. % of the preparation of Xidifone (K, Na salt of 1-hydroxyethylidenebiphosphonic acid) and 99.5-97 wt. % of any acceptable base / RF, patent 2101015; A 61 K 31/66, 1998 /. However, the known agent is preferably used in the treatment of neurological diseases and diseases of the musculoskeletal system and is not very effective as a decongestant, therefore, in practice, especially in the field of cosmetology, as a decongestant is practically not used.
The new invention is an externala decongestant containing a base, a phosphonate additive and soluble magnesium salts with a weight content of magnesium salts of 0.1-30 wt%, a phosphonate additive of 0.01-10 wt%. The external agent is made in the form of a cream, ointment, gel, emulsion, lotion. The agent can additionally contain medicinal, biologically active, aromatic additives in an effective amount. The new invention differs from the prototype in that it contains the desired additive, the soluble magnesium salt, in a certain effective amount (0.1-30 wt.%), Which results in a synergistic anti-edematous effect confirmed by clinical studies. Any physiologically acceptable salt such as chloride, acetate, sulfate, etc. can be used as magnesium salts. The choice of the claimed amounts of the magnesium salt content is determined by the effectiveness, the absence of side effects and the stability of the composition. As another effective additive, any physiologically acceptable phosphonate-containing compounds or a mixture thereof is used. As such a compound, the following known compounds can be used: oxymethylene bisphosphonic acid and its salts, hydroxyethylidene bisphosphonic acid and its salts, phosphonoformic acid and its salts, ethylenediaminotetramephthalic acid and its salts, etc. These compounds may be present in an amount of 0.01-10% by weight, as determined by the efficacy and stability of the formulation.
The invention is illustrated below by specific formulations in the form of a cream, ointment, gel, lotion.
1. An example of a composition of a decongestant cream containing 0.7% magnesium salt and 1.0% phosphonate additive.
Component% wt.
The basis:
Stearin - 2.0
Glycerol monostearate - 1.5
Higher fatty alcohols С16-С20 - 1,0
Vegetable oil (olive oil) - 6,0
Perfume oil - 4,0
Lanolin anhydrous - 0,8
Triethanolamine 1.6
Additives:
Magnesium sulphate 7-water - 0.7
K, Na salt of 1-hydroxyethylidenebiphosphonic acid 1.0
Extract color. linden - 1.0
Extract of althea root - 1.0
Preservative, perfume - q.s.
Water - Up to 100%
2. An example of a composition of a decongestant containing 1.5% magnesium salt and 2.0% phosphonate additive.
Component% wt.
The basis:
Glycerol Oleate - 12.0
Potassium dialkylphosphate 4.0
Vaseline oil - 42.0
Lanolin anhydrous - 1.0
Additives:
Magnesium sulphate 7-water - 1,5
Ethylenediaminotetramethylphosphonic acid 2.0
Menthol racemic - 0.5
Preservative - q.s.
Water - Up to 100%
3. An example of a composition of a decongestant gel containing 1.8% magnesium salt and 2.0% phosphonate additive.
Component% wt.
The basis:
Sodium alginate - 0.1 - 0.2
Glycerol - 1.0
Additives:
Magnesium chloride 6-water - 1,8
Ethylenediaminotetramethylphosphonic acid 2.0
Essential oil of tea tree - 0,3
Preservative, perfume, color - q.s.
Sodium hydroxide - Up to pH 7.0
Water - Up to 100%
4. An example of the composition of an anti-edematic lotion containing 0.7% magnesium salt and 0.5% phosphonate additive.
Component% wt.
The basis:
PEG-40 hydrogenated castor oil - 0.1
Sodium carboxymethyl cellulose 0.1
Propylene glycol 1.5
Ethyl alcohol - 15.0 - 20.0
Additives:
Magnesium chloride 6-water - 0,7
Oxymethylenebisphosphonic acid - 0.5
Green Tea Extract - 2.0
Lavender essential oil - 0.2
The dye is q.s.
Water - Up to 100% g

1. An external decongestant comprising a base and a phosphonate target additive, characterized in that it further comprises soluble magnesium salts at the following weight ratio of the components of the mixture, %:
Phosphonate target additive - 0.01-10
Soluble magnesium salt - 0.1-30
Basis - Other
2. The external decongestant according to claim 1, characterized in that it is formulated as an ointment, cream, gel, lotion.
3. The agent according to 1 and 2, characterized in that it further contains medicinal and / or flavoring and / or biologically active additives.

Comments 3

Tatyana
Tatyana on 22 June 2016 12:20
Hello! I have a problem here in what.a year ago I broke my right leg, two bones .... I now have a very strong leg to the knee, I grish that this may be due to my work, I stand on my feet 12-13 hours or from an internal occlusion. I read in the newspaper that you can order from you Imultima ... blush can at least it helps me .... I can not drink diuretic pills, by the fact that the problem with mochivykom, tell me what to do disappointed
Inna
Inna from 8 July 2016 15:13
I would like to know the price of this drug
Valery
Valery of 17 July 2016 09:25
I would like to know the price of this drug. Amount in a package. Reviews