Pulmonary edema on pneumonia
It is known that half of patients with pneumococcalpneumonia dies because of toxins released by bacteria. The international team of scientists was able to find a method against the second wave of death - the addition of an agonist that mimics the effect of growth hormone.
Problems begin when the bacterium pneumococcusgets into the respiratory tract. Begin the accumulation of mucus, cough, fever, chills, difficulty breathing. Antibiotics help to destroy the infection, but bacteria already have time to develop pneumolysin, a dangerous toxin that is eating holes in the alveoli (air bags of the lungs) and blood vessels.
Pneumolysin binds to cholesterol,component of all cell membranes. When combined, it releases substances that leave gaps in the cells of the alveoli and capillaries. Alveoli usually serve to replenish blood with oxygen and remove carbon dioxide. If the membranes are damaged, the liquid from the capillaries penetrates into the air sacs, and also fills the space between them. In addition, the toxin blocks the protective systems of sodium absorption in the lungs, because the liquid is not removed on time. In a few days the patient's life is again in danger.
Dr. Andrew B. Shalli, the Nobel Prize winner for the discovery of the hormones of the hypothalamus, the head of the department of endocrinology and the cancer institute, developed agonists who might one day save these patients. Previously, they were used to protect the heart muscle after a heart attack.
Scientists have detected receptors for growth hormone incells lining the alveoli. The use of growth hormone releasing hormone in animals, as well as testing on human lung cells in test tubes, showed that the sodium system was restored.
They say that the use of agonists will help to avoid the dangerous accumulation of fluid in the lungs.
February 1, 2012 at 16:25